The anti-allergome resource

One of the partner in the molecular recognition event that eventually initiates the type I hypersensitivity reaction, that is. IgE or Immunoglobulin E, is poorly characterized at the molecular level. Recently, however, efforts to define human IgE as found in allergic individuals have met with some success.

A set of research teams have, using genetic engineering, isolated human IgE or fragments thereof derived from human subjects. Collectively they represent the first members of an Anti-Allergome Resouce, that is sets of IgE representing the human antibody reponse that can interact with the much more extensively characterized Allergome, the set of allergenic proteins that induce type I hypersensitivity reactions by activating effector cells of the immune system that carry IgE.

This page carry molecular information about members of the human Anti-Allergome, that is of allergen-bindning monoclonal antibodies or fragments thereof derived from human IgE-producing B lymphocytes.

 

Allergen sourceAllergenClone namesGenBank entryReference
Phleum pratensePhl p 1P1-15, P1-19, P1-20EF607094-EF607096Persson et al., 2007
Phleum pratensePhl p 15p1:3, 1p1:8JX169823-JX169824Levin et al., 2013
Phleum pratensePhl p 2P2-2, P2-13, P2-18, P2-22, P2-29, P2-33EF607097-EF607102Persson et al., 2007
Phleum pratensePhl p 2CIP2
Phleum pratensePhl p 4p4-1, p4-2, p4-4, p4-5, p4-7, p4-11, p4-24, p4-28EF607103-EF607110Persson et al., 2007
Phleum pratensePhl p 54.1, 4.2, 4.3, 4.4, 4.10, 4.12, 4.13DQ065729-DQ065735Andréasson et al., 2006
Phleum pratensePhl p 5p5-1, p5-3, p5-8, p5-9, p5-11, p5-13, p5-16, p5-17, p5-18EF607111-EF607119Persson et al., 2007
Phleum pratensePhl p 5P5-AB10, P5-AB12, P5-AB14, P5MA3, P5-MA4, P5-MA14, P5-MA15, P5-MB10EU090053-EU090060Persson et al., 2008
Phleum pratensePhl p 6p6-1, p6-12, p6-19, p6-21, p6-36EF607121-EF607124Persson et al., 2007
Phleum pratensePhl p 11p11-4, p11-5, p11-8, p11-16EF607125-EF607128Persson et al., 2007
Dermatophagoides pteronyssinusDer p 2H04_B04MK937271Glesner et al., 2019
Betula verrucosaBet v 1B10, B13, B14, M0418KF240714-KF240717Levin et al., 2014

 

These antibody fragments are available for scientific collaboration.

Please contact Mats Ohlin.

Page Manager: jana.hladilkova@immun.lth.se | 2021-04-12