Transcriptional and protein profiling in tissue
Transcriptional and protein profiling
Advancement within precision medicine and companion diagnostics, will only be made by increasing the understanding of the interplay between the tumor cells and the adjacent microenvironment and tentative protective niches. In the immunotherapy era, this is increasingly important as immune status at diagnosis ultimately will determine the capacity of the immune system to raise a functional response.
In ongoing projects, mutational and immune status of mantle cell lymphoma patients from the Nordic Mantle Cell Lymphoma 2/3 clinical trial, and the population-based cohort BLISS is characterized with the aim to improve biological understanding and develop methods for improved treatment selection.