Faculty of Engineering, LTH

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Literature references 1990-1999


  1. Andersson, E., Henderikx, P., Krambovitis, E., Hoogenboom, H. R. and Borrebaeck, C. A. K. (1999) A tandem repeat of MUC1 core protein induces a weak in vitro immune response in human B cells. Cancer Immunol. Immunother. 47, 249-256.
  2. Malmborg AC (1999) Phage display method. In: Real-time analysis of biomolecular interactions - applications of BIACORE (Japanese edition). (Eds.: Nagata K, Handa H ) Springer-Verlag, Tokyo. pp. 194-200.
  3. Söderlind E, Ohlin M and Carlsson R (1999) CDR implantation: a theme of recombination. Immunotechnology 4, 279-285.
  4. Malmborg AC and Ohlin M (1999) Characterization of bacteriophages by the use of BIAcore and Origen analyzer. Intern. J. Biochromatography 4, 163-173.
  5. Dueñas M, Rodríguez E, Nilsson N, Everitt E and Borrebaeck CAK (1999) Synthesis of a eukaryotic virus protein in a prokaryotic viral-cell system: production of the adenovirus type 2 fiber shaft fragment by a tightly regulatable T7pol-M13 expression system. J. Virol. Methods 79, 121-131.
  6. Andersson T, Furebring C, Borrebaeck CAK and Pettersson S (1999) Temporal expression of a VH promotor-Cµ transgene linked to the IgH HS1,2 enhancer. Mol. Immunol. 36, 19-29.
  7. Ingvarsson S, Dahlenborg K, Carlsson R and Borrebaeck CAK (1999) Coligation of CD44 on naive human tonsillar B cells induces a germinal center phenotype. Int. Immunol. 11, 739-744.
  8. Speckner A, Glykofrydes D, Ohlin M and Mach M (1999) Antigenic domain 1 of human cytomegalovirus glycoprotein B induces a multitude of different antibodies which, when combined, results in incomplete virus neutralization . J. Gen. Virol. 80, 2183-2191.
  9. Borrebaeck CAK (1999) Human monoclonal antibodies - The emperors new cloths? Nat. Biotechnol. 17, 621.


  1. Faber C, Shan L, Fan Z-C, Guddat LW, Furebring C, Ohlin M, Borrebaeck CAK and Edmundson AB (1998) Three-dimensional structure of human Fab with high affinity for tetanus toxoid. Immunotechnology 3, 253-270.
  2. Edmundson AB and Borrebaeck CAK (1998) Progress in programming antibody fragments to crystallize. Immunotechnology 3, 309-317.
  3. Strandh, M., Ohlin, M., Borrebaeck, C. A. K. and Ohlson, S. (1998) New approach to steroid separation based on a low affinity IgM antibody. J. Immunol. Methods 214, 73-79.
  4. Ohlin, M. and Borrebaeck, C. A. K. (1998) Insertions and deletions in hypervariable loops of antibody heavy chains contribute to molecular diversity. Mol. Immunol. 35, 233-238. (supplementary data)
  5. Edmundson AB, Goldsteen BZ, DeWitt CR, Fan Z-c, Shan L, Faber C, Hanson L and Borrebaeck CAK (1998) Designing Fabs and Fvs with propensities to crystallize. The Immunologist 6, 54-67.
  6. Jirholt P, Ohlin M, Borrebaeck CAK and Söderlind E (1998) Exploiting sequence space: shuffling in vivo formed complementarity determining regions into a master framework. Gene 215, 471-476.
  7. Eickmann, M., Lange, R., Ohlin, M., Reschke, M. and Radsak, K. (1998) Effect of cysteine substitutions on dimerization and interfragment linkage of human cytomegalovirus glycoprotein B (gpUL55). Arch. Virol. 143, 1865-1880.
  8. Ohlin M, Jirholt P, Thorsteinsdottir HB, Lantto J, Lindroth Y and Borrebaeck CAK (1998) CDR-shuffling: targeting hyper-variable loops for library construction and selection. In: Proceedings of the 10th International Congress of Immunology. Monduzzi Editore, Bologna. p 1525-1529.
  9. Borrebaeck CAK (1998) Tapping the potential of molecular libraries in functional genomics. Immunol. Today 19, 524-527.
  10. Cruz S, Musacchio A, Fernandez-de-Cossio ME, Ohlin M, Nazabal C, Freyre F, Borrebaeck CAK and Gavilondo JV (1998) Mouse monoclonal antibodies against outer membrane proteins of a vaccine strain of Neisseria meningitidis B:4:P1.15. Minerva Biotec. 10, 65-70.
  11. Malmborg AC, Shultz DB, Luton F, Mostov KE, Richly E, Leung PSC, Benson GD, Ansari AA, Coppel RL, Gershwin ME and Van de Water J (1998) Penetration and co-localization in MDCK cell mitochondria of IgA derived from patients with primary biliary cirrhosis. J. Autoimmun. 11, 573-580.
  12. Ni J, Fernandez MA, Danielsson L, Chillakuru RA, Zhang J, Grubb A, Su J, Gentz R, Abrahamson M. (1998) Cystatin F is a glycosylated human low molecular weight cysteine proteinase inhibitor. J. Biol. Chem. 273, 24797-24804.


  1. Dueñas M, Casalvilla R, Malmborg A-C, Chin LT, Ohlin M and Borrebaeck CAK (1997) The SAP as a homogenous and kinetic based selection system for active proteins in combinatorial libraries. Biotec. Aplicada 14, 51-52.
  2. Dahlenborg K, Hultman L, Carlsson R and Jansson B (1997) Human monoclonal antibodies specific for the tumour associated Thomsen-Friedenreich antigen. Int. J. Cancer 70, 63-71.
  3. Zafiropoulos A, Andersson E, Krambovitis E and Borrebaeck CAK (1997) Induction of antigen-specific isotype switching by in vitro immunization of human naive B lymphocytes. J. Immunol. Methods 200, 181-190.
  4. Ohlin M, Silvestri M, Sundqvist V-A and Borrebaeck CAK (1997) Cytomegalovirus glycoprotein B-specific antibody analysis using electrochemiluminescence detection-based techniques. Clin. Diagn. Lab. Immunol. 4, 107-111.
  5. Furebring C, Ohlin M, Pettersson S and Borrebaeck CAK (1997) Evaluation of novel control elements by construction of eukaryotic expression vectors. Gene 188, 191-198.
  6. Dahlenborg K, Pound JD, Gordon J, Borrebaeck CAK and Carlsson R (1997) Terminal differentiation of human germinal center B cells in vitro. Cell. Immunol. 175, 141-149. Nilsson N, Wallén-Öhman M, Ohlin M and Borrebaeck CAK (1997) Altered gene expression associated with apoptosis in a pre-B leukemic cell line following cross-linking of MHC class I. Exp. Cell Res. 231, 190-197.
  7. Wallén-Öhman M, Larrick JW, Carlsson R and Borrebaeck CAK (1997) Ligation of MHC class I induces apoptosis in human pre-B cell lines, in promyelocytic cell lines and in CD40 stimulated mature B cells. Int. Immunol. 9, 599-606.
  8. Kobayashi N, Söderlind E and Borrebaeck CAK (1997) Analysis of assembly of synthetic antibody fragments: expression of functional scFv with predefined specificity. Biotechniques 23, 500-503.
  9. Borrebaeck CAK, Söderlind E, Frost LS and Malmborg A-C (1997) Combining bacterial and phage display: tapping the potential of molecular libraries for gene identification. In: Display Technologies. Novel targets and strategies. (Eds.: Guttry P, Savage LM ) International Business Communications, Inc., Southborough, MA. pp197-208.
  10. Xuhua H, Shen L, Malmborg A-C, Smith KJ, Dahlbäck B and Linse S (1997) Binding site for C4b-binding protein in vitamin K-dependent protein S fully contained in carboxy-terminal laminin-G-type repeats. A study using recombinant factor IX-protein S chimeras and surface plasmon resonance. Biochemistry 36, 3745-3754.
  11. Malmborg A-C, Söderlind E, Frost L and Borrebaeck CAK (1997) Selective phage infection mediated by epitope expression on F pilus. J. Mol. Biol. 273, 544-551.


  1. Ohlin M, Owman H, Mach M and Borrebaeck C A K (1996) Light chain shuffling of a high affinity antibody results in a drift in epitope recognition. Mol. Immunol. 33, 47-56.
  2. Dueñas M, Malmborg A-C, Casalvilla R, Ohlin M and Borrebaeck C A K (1996) Selection of phage displayed antibodies based on kinetic constants. Mol. Immunol. 33, 279-285.
  3. Schoppel K, Hassfurther E, Britt W, Ohlin M, Borrebaeck C A K and Mach M (1996) Antibodies specific for the antigenic domain 1 of glycoprotein B (gpUL55) of human cytomegalovirus bind to different substructures. Virology 216, 133-145.
  4. Ohlin M and Borrebaeck C A K (1996) Low affinity antibody binding of an Escerichia coli-derived component. FEMS Immunol. Med. Microbiol.13, 161-168.
  5. Andersson E, Dahlenborg K, Ohlin M, Borrebaeck CAK and Carlsson R (1996) Immunoglobulin production induced by GC-derived helper T cells in vitro require addition of exogenous IL-2. Cell. Immunol. 169, 166-173.
  6. Ohlin M and Borrebaeck CAK (1996) Characteristics of human antibody repertoires following active immune responses in vivo. Mol. Immunol. 33, 583-592.
  7. Ohlin M, Furebring C and Borrebaeck CAK (1996) Low affinity binding of human immunoglobulin variable domains. A new superantigen in Escherichia coli? In: Human B-cell superantigens. (Ed. M. Zouali). R. G. Landes Bioscience Publishers, Austin, TX, USA pp 113-119.
  8. Norrback K-F, Dahlenborg K, Carlsson R and Roos G (1996) Telomerase activation in normal B lymphocytes and non-Hodgkin's lymphomas. Blood 88, 222-229.
  9. Arulampalam V, Furebring C, Samuelsson A, Lendahl U, Borrebaeck C, Lundkvist I and Pettersson S (1996) Elevated expression levels of an immunoglobulin transgene links the IgH 3' enhancer to the regulation of IgH expression. Int. Immunol. 8, 1149-1157.
  10. Ifversen M and Borrebaeck CAK (1996) SCID-hu-PBL: A model for making human antibodies? Semin. Immunol. 8, 243-248.
  11. Bold S, Ohlin M, Garten W and Radsak K (1996) Structural domains involved in human cytomegalovirus glycoprotein B mediated cell-cell fusion. J. Gen. Virol. 77, 2297-2302.
  12. Dueñas M, Chin L-t, Malmborg A-C, Casalvilla R, Ohlin M and Borrebaeck CAK (1996) Secondary in vitro immunization yields high affinity immunoglobulin G antibodies as illustrated by phage display. Immunology 89, 1-7.
  13. Malmborg A-C, Dueñas M, Ohlin M, Söderlind E and Borrebaeck CAK (1996) Selection of binders from phage displayed antibody libraries using BIAcoreª biosensor. J. Immunol. Methods 198, 51-57.


  1. Andersson E, Ohlin M, Borrebaeck C A K and Carlsson R (1995) CD4+CD57+ cells derived from peripheral blood do not support immunoglobulin production by B cells. Cell. Immunol. 163, 245-253.
  2. Dueñas M, Ayala M, Vazquez J, Ohlin M, Söderlind E, Borrebaeck C A K and Gavilondo J V (1995) A single nucleotide mutation in the immunoglobulin V-region strongly influences the level of antibody gene expression in E. coli. Gene 158, 61-66.
  3. Ohlin M, Plachter B, Sundqvist V-A, Middeldorp J M, Steenbakkers P G A and Borrebaeck C A K (1995) Human antibody reactivity against the lower matrix protein (pp65) produced by cytomegalovirus. Clin. Diagn. Lab. Immunol. 2, 325-329.
  4. Rioux J D, Ohlin M, Borrebaeck C A K and Newkirk M M (1995) Molecular characterization of human monoclonal antibodies specific for the human cytomegalovirus: Relationship of variable region sequence to antigen specificity and rheumatoid factor-associated idiotype expression. Immunother. Infect. Dis. 5, 43-52.
  5. Malmborg A and Borrebaeck C A K (1995) BIAcoreª as a tool in antibody engineering. J. Immunol. Methods 183, 7-13.
  6. Ifversen P, Mårtensson C, Danielsson L, Ingvar C, Carlsson R and Borrebaeck C A K (1995) Induction of primary antigen-specific responses in Scid-hu-PBL by coupled T-B epitopes. Immunology 84, 111-116.
  7. Söderlind E, Vergeles M and Borrebaeck C A K (1995) Domain libraries: Synthetic diversity for de novo design of antibody fragments. Gene 160, 269-272.
  8. Lagerkvist A C S, Furebring C and Borrebaeck C A K (1995) Single, antigen-specific B cells used to generate Fab fragments using CD40-mediated amplification or direct PCR cloning. Biotechniques 18, 862-869.
  9. Ingvarsson S, Simonsson Lagerkvist A C, Mårtensson C, Granberg U, Ifversen P, Borrebaeck C A K and Carlsson R (1995) Antigen-specific activation of B cells in viro after recuitment of T cell help with superantigen. Immunotechnology 1, 29-39.
  10. Ingvarsson S, Simonsson Lagerkvist A C, Carlsson R and Borrebaeck C A K (1995) Stimultion of human peripheral lymphocytes via CD3 and soluble antigen abrogates specific antibody production by reducing memory B cell numbers. Scand. J. Immunol. 42, 331-336.
  11. Malmborg A-C, Johansson K, Sigvardsson M, Borrebaeck C A K and Leandersson T (1995) Real-time analysis of Oct protein/octamer interaction and transcription complex assembly. Mol. Immunol. 32, 1429-1442.
  12. Chin L-T, Malmborg A-C, Kristensson K, Hinkula J, Wahren B and Borrebaeck C A K (1995) Mimicking the humoral immune response in vitro results in antigen-specific isotype switching supported by specific autologous T helper cells: generation of human HIV-1-neutralizing IgG monoclonal antibodies from naive donors. Eur. J. Immunol. 25, 657-663.
  13. Chin L-T, Dueñas M, Levi M, Hinkula J, Wahren B and Borrebaeck C A K (1995) Molecular characterization of a human anti-HIV 1 monoclonal antibody revealed a CD26-related motif in CDR2. Immunol. Lett. 44, 25-30.
  14. Dueñas M and Borrebaeck C A K (1995) Novel helper phage design: intergenic region affects the assembly of bacteriophages and the size of antibody libraries. FEMS Microbiol. Lett. 125, 317-321.
  15. Söderlind E, Duenas M and Borrebaeck C A K (1995) Chaperonins in phage display of antibody fragments. In: Methods in Molecular Biology Series (vol 51): Antibody Engineering Protocols. (Paul S, Ed.). Humana Press Inc, Totowa, NJ, pp 343-353.
  16. Mårtensson C, Ifversen P, Borrebaeck C A K and Carlsson R (1995) Enhancement of specific immunoglobulin production in SCID-hu-PBL mice after in vitro priming of human B cells with superantigen. Immunology 86, 224-230.
  17. Wingren C, Hansson U-B, Magnusson C G M and Ohlin M (1995) Antigen-binding sites dominate the surface properties of IgG antibodies. Mol. Immunol. 32, 819-827.
  18. Rioux J D, Brodeur B, Larose Y, Ohlin M, Borrebaeck C A K and Newkirk M M (1995) Generation of diversity in a human anti-viral response. In: Immunoglobulin gene expression in development and Disease. Ann. New York Acad. Sci. 764, 381-383.
  19. Ohlin M, Owman H, Mach M, Sundqvist V-A and Borrebaeck C A K (1995) Light chain shuffling of a cytomegalovirus glycoprotein B-specific antibody results in a modified epitope specificity. Scand. J. Infect. Dis. Suppl. 99, 24.
  20. Wahren B, Hinkula J, Ljungdahl Ståhle E, Borrebaeck CAK, Schwartz S and Wigzell H (1995) Nucleic acid vaccination with HIV regulatory genes. Ann. New York Acad. Sci. 772: 278-281.


  1. Chin L-T, Hinkula J, Levi M, Ohlin M, Wahren B and Borrebaeck C A K (1994) Site-directed primary in vitro immunization: production of HIV-1 neutralizing human monoclonal antibodies from lymphocytes obtained from seronegative donors. Immunology 81, 428-434.
  2. Wallén Öhman M and Borrebaeck C A K (1994) A cell surface antigen (BAL) defined by a mouse monoclonal antibody inducing apoptosis in a human acute lymphocytic leukemia cell line. Int. J. Cancer 57, 544-552.
  3. Dueñas M, Vázquez J, Ayala M, Söderlind E, Ohlin M, Pérez L, Borrebaeck C A K and Gavilondo J V (1994) Intra- and extracellular expression of an scFv antibody fragment in E. coli: Effect of bacterial strains and pathway engineering using GroES/L chaperonins. BioTechniques 16, 476-483.
  4. Ohlin M and Borrebaeck C A K (1994) Flow cytometric analysis of the stability of antibody production by human x human x mouse heterohybridoma subclones. J. Immunol. Methods 170, 75-82.
  5. Kristensson K, Kristensen L, Borrebaeck C A K and Carlsson R (1994) Activation of CD4+CD45RA+ T cells using B cells as accessory cells. Immunol. Lett. 39, 223-229.
  6. Ohlin M, Owman H, Rioux J D, Newkirk M M and Borrebaeck C A K (1994) Restricted variable region gene usage and possible rheumatoid factor relationship among human monoclonal antibodies specific for the AD-1 epitope on cytomegalovirus glycoprotein B. Mol. Immunol. 31, 983-991.
  7. Hardy E, Ohlin M and Llano M (1994) Enhanced ELISA sensitivity using TCA for efficient coating of biologically active lipopolysaccharides or lipid A to the solid phase. J. Immunol. Methods 176, 111-116.
  8. Dueñas M and Borrebaeck C A K (1994) Clonal selection and amplification of phage displayed antibodies by linking antigenic recognition and phage replication. Bio/Technology 12, 999-1002
  9. Mårtensson C, Kristensson K, Kalliomäki S, Borrebaeck C A K and Carlsson R (1994) Antigen-specific human immunoglobulin production in SCID mice transplanted with human peripheral lymphocytes is dependent on CD4+CD45R0+ cells. Immunology 83, 171-179.
  10. Chin L-t, Ifversen P, Kristensson K, Wahren B, Carlsson R and Borrebaeck C A K (1994) Human Th0-type T helper cell clone supports antigen-specific immunoglobulin production in scid/beige-hu mice. Scand. J. Immunol. 40, 529-534.
  11. Ohlin, M. and Borrebaeck, C. A. K. (1994) Immunotechnology (invited book review). Immunol. Today 15, 499-500.


  1. Borrebaeck C A K, Mårtensson C, Ifversen P and Carlsson R (1993) Evaluation of the scid-hu mouse as a model to generate human monoclonal antibodies. In: Monoclonal Antibodies. Applications in Clinical Oncology (Epenetos A, Ed), Chapman & Hall Medical, London, Chap 50, pp. 481-493.
  2. Ohlin M, Sundqvist V-A, Mach M, Wahren B and Borrebaeck C A K (1993) Fine specificity of the human immune response to the major neutralization epitopes expressed on cytomegalovirus gp58/116 (gB) as determined with human monoclonal antibodies. J. Virol. 67, 703-710.
  3. Borrebaeck C A K and Ohlin M (1993) In vitro immunization of peripheral lymphocytes for the production of human monoclonal antibodies. In: Cell & Tissue Culture: Laboratory Procedures, (Doyle A, Griffiths J B, Newell D G, Eds), John Wiley & Sons Ltd., Chichester, UK. 25E:1.1-7.
  4. Söderlind E, Simonsson Lagerkvist A C, Dueñas M, Malmborg A-C, Ayala Avila M, Danielsson L and Borrebaeck C A K (1993) Chaperonin assisted phage display of antibody fragments on filamentous bacteriophages. Bio/Technology 11, 503-507.
  5. Ifversen P, Zhang X-M, Ohlin M, Zeuthen J and Borrebaeck C A K (1993) Effect of cell-derived growth factors and cytokines on the clonal outgrowth of EBVinfected cells and established lymphoblastoid cell lines. Hum. Antibod. Hybridomas 4, 115-123.
  6. Ayala Avila M, Vázques J, Danielsson L, Fernández de Cossío M E and Borrebaeck C A K (1993) Sequence determination of variable region genes of two human monoclonal antibodies against Neisseria meningitides. Gene 127, 273-274.
  7. Borrebaeck C A K, Malmborg A-C and Ohlin M (1993) Does endogenous glycosylation prevent the use of mouse monoclonal antibodies as cancer therapeutics? Immunol. Today 14, 477-479.
  8. Silvestri M, Jäderling F, Rudén U, Ohlin M and Sundqvist V-A (1993) Fine specificity and neutralizing activity of human serum antibodies directed to the major antigenic region on gp116 of human cytomegalovirus. Serodiagn. Immunother. Infect. Dis. 5, 209-216.
  9. Wallén-Öhman M, Lönnbro P, Schön A and Borrebaeck C A K (1993) Antibody-induced apoptosis in a human leukemia cell line is energy dependent: Thermochemical analysis of cellular metabolism. Cancer Lett. 75, 103-109.
  10. Dueñas M, Ayala Avila M, Vazquez J, Ohlin M, Borrebaeck C A K and Gavilondo J V (1993) Immunoglobulin V-region sequence can determine expression of bacterial Fab antibody fragments. Prot. Eng. 6 (suppl) 87.
  11. Vázquez J E, Ayala M, Danielsson L, Fernández de Cossío ME, Cruz S, Nazábal C, Mussachio A, Silva R, Borrebaeck C A K, Zollinger W D and Gavilondo J V (1993) DNA sequences of two bactericidal IgG2b monoclonal antibodies specific for class 3 outer membrane protein of Neisseria meningitidis B:4:P1.15. Biotecnologia Aplicada 10, 119-124.


  1. Carlsson R, Mårtensson C, Kalliomäki S, Ohlin M and Borrebaeck C A K (1992) Human peripheral blood lymphocytes transplanted into SCID mice constitute an in vivo culture system exhibiting several parameters found in a normal humoral immune response and are the source of immunocytes for the production of human monoclonal antibodies. J. Immunol. 148, 1065-1071.
  2. Kristensson K, Borrebaeck C A K and Carlsson R (1992) Human CD4+ T cells expressing CD45RA acquire the lymphokine gene expression of CD45R0+ T helper cells after activation in vitro. Immunology 76, 103-109.
  3. Malmborg A-C, Michaëlsson A, Ohlin M, Jansson B and Borrebaeck C A K (1992) Real time analysis of antibody - antigen reaction kinetics. Scand. J. Immunol. 35, 643-650.
  4. Ohlin M, Hinkula J, Broliden P-A, Grünow R, Borrebaeck C A K and Wahren B (1992) Human monoclonal antibodies produced from normal, HIV-1 seronegative donors and specific for glycoprotein gp120 of the HIV-1 envelope. Clin. Exp. Immunol. 89, 290-295.
  5. Borrebaeck C A K, Malmborg A-C, Furebring C, Michaelsson A, Ward S, Danielsson L and Ohlin M (1992) Kinetic analysis of recombinant antibody-antigen interactions: Relation between structural domains and antigen binding. Bio/Technology 10, 697-698.
  6. Fernández de Cossío M E, Ohlin M, Llano M, Selander B, Cruz S, del Valle J and Borrebaeck C A K (1992) Human monoclonal antibodies against an epitope on the class 5c outer membrane protein common to many pathogenic strains of Neisseria meningitidis. J. Infect. Dis. 166, 1322-1328.
  7. Söderlind E, Simonsson A C and Borrebaeck C A K (1992) Phage display technology in antibody engineering: Design of phagemid vectors and in vitro maturation systems. Immunol. Rev. 130, 109-124.
  8. Ohlin M, Kristensson K, Carlsson R, and Borrebaeck C A K (1992) Epstein-Barr Virus-induced transformation of human B lymphocytes: The effect of L-Leucyl-L-Leucine methyl ester on inhibitory T cell populations. Immunol. Lett. 34, 221-228.


  1. Ohlin M, Sundqvist V-A, Gilliam G, Rudén U, Gombert F O, Wahren B and Borrebaeck C A K (1991) Characterization of human monoclonal antibodies directed against the pp65 KD matrix antigen of human cytomegalovirus. Clin. Exp. Immunol. 84, 508-514.
  2. Wallén M and Borrebaeck C A K (1991) The affinity repertoire of monoclonal antibodies obtained by primary or secondary in vitro immunization. Hybridoma 10, 333-345.
  3. Danielsson L, Furebring C, Ohlin M, Hultman L, Abrahamson M, Carlsson R and Borrebaeck C A K (1991) Human monoclonal antibodies with different finespecificity for digoxin derivatives: Cloning of heavy and light chain variable region sequences. Immunology 74, 50-54.
  4. Sjögren-Jansson E, Ohlin M, Borrebaeck C A K and Jeansson S (1991) Production of human monoclonal antibodies in dialysis tubing. Hybridoma 10, 411-419.
  5. Jansson B, Carlsson R and Borrebaeck C A K (1991) The human repertoire of antibody specificities against Thomsen-Friedenreich and Tn carcinoma associated antigens as defined by human monoclonal antibodies. Cancer Immunol. Immunotherapy 34, 294-298.
  6. Simonsson A C, Larrick J W and Borrebaeck C A K (1991) In vitro immunization of human B lymphocytes. MAPPing of human lymphokine specific mRNA and the effect of recombinant factors. Hum. Antibod. Hybridomas 2, 148-154.
  7. Ohlin M and Borrebaeck C A K (1991) Production of human monoclonal antibodies. In: Methods of Immunological Analysis, Vol 2 (Masseyeff R. Ed), Chapter 4, VCH Verlagsgesellschaft mbH, Weinheim, FRG.
  8. Danielsson L and Borrebaeck C A K (1991) Amplification of rearranged Ig variable region DNA from single cells, In: Antibody Engineering (Borrebaeck C A K. Ed), W H Freeman Publishing Co, New York. pp.89-102.


  1. Möller S A, Birkedal S and Borrebaeck C A K (1990) High affinity human IgM monoclonal antibodies against Mycoplasma hominis. J. Clin. Lab. Anal. 4, 390-395.
  2. Zhang X-M and Borrebaeck C A K (1990) Human monoclonal antibodies. In vitro immunization of human B lymphocytes with cultured melanoma cells (SK-MEL-28). Hum. Antibod. Hybridomas 1, 42-46.
  3. Borrebaeck C A K, Danielsson L, Ohlin M, Carlsson J and Carlsson R (1990) The use of in vitro immunization, cloning of variable regions, and SCID mice for the production of human monoclonal antibodies. In: Therapeutic Monoclonal Antibodies (Borrebaeck C A K and Larrick J W, Eds), Stockton Press, New York. pp.1.

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